Langerin conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
نویسندگان
چکیده
Department of Immunology, Erasmus MC, University Medical Center, 3015 GE, Rotterdam, The Netherlands; Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032; Center of Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, 80802 Munich, Germany; Department of Neurobiology, Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland; Department of Microbiology and Immunology, University of Montréal, Montréal, QC, Canada H2W 1R7; Department of Dermatology, Erasmus MC, University Medical Center, 3000 CA, Rotterdam, The Netherlands; Department of Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany; and Department of Surgery, Klinikum Rechts der Isar, Technical University Munich, 81675 Munich, Germany
منابع مشابه
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.
Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis. Likewise, in mice IMQ triggers pathological changes closely resembling psoriatic plaque formation. Key cytokines like IL-23 and type-I IFN (IFN-I), both being produced mainly by dendriti...
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